Abstract
Background: The thyroid hormones are protein-bound in the serum, and only 0.02% of T4 and 0.2% of T3 are free, biologically active hormones. 45–70% of thyroid hormones are bound to thyroxine-binding globulin (TBG), and the rest to transthyretin and albumin. Familial conditions, estrogen treatment and pregnancy may have effects on the concentrations of the binding proteins, leading to changes in thyroid hormone fractions until a new equilibrium is reached.
Materials and Methods.Thyroid function tests were performed by chemiluminescent microparticle immunoassay (CMIA) for the quantitative determination of thyroid hormones (Total T3, Total T4 and TSH) .In human serum and plasma values were presented as mean ± standard deviation. Student t’ test was used to compare hormonal levels. The corresponding value of 'p' was obtained from the standard table of critical 't' values at the appropriate degree of freedom. Statistical significance was considered as p<0.05.
Conclusion. The findings of present study indicate that as the severity of preeclampsia increases the level of TSH increases with corresponding decrease in T3, T4.